General Information

  • ID:  hor001134
  • Uniprot ID:  A0A1S4FZK7
  • Protein name:  FMRFamide-3
  • Gene name:  NA
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AGQGFMRF
  • Length:  8
  • Propeptide:  MKMYLFLAILIYKCSNYFSCAEYELAEASQAVNGPSIALDLNPESENDFTNNNNGMVFEFRRSIKSDNTEIEARRRSALDKNFMRFGRTDPTALQRVARASKQANLMRFGRAGQGFMRFGRIPENVPLSLVHNDDDSRQDYNGDSEESSEETTYSKRTPNSDEITEVSESGEQIKPKQLVYYRRDSPKNLMRFGKRDDTNKFLRLSRANLMRFGRAGSEAGGNLQRTNFLRFGRGSGNLMRFGRAKGNLMRFGRSDPRFLRLVKMDNNFMRFGRSDKALKSVDKNETRSSESSTSHNNEIISETKHHDDLSLDKTDAPYKSDEDYEIQLREEDILTPVFVSNY
  • Signal peptide:  MKMYLFLAILIYKCSNYFSCA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor001134_AF2.pdbhor001134_ESM.pdb

Physical Information

Mass: 103810 Formula: C41H60N12O10S
Absent amino acids: CDEHIKLNPSTVWY Common amino acids: FG
pI: 10.55 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: 6.25 Boman Index: -846
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 12.5
Instability Index: -67.5 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti